The journal to enhance your knowledge of cleanroom, clean air and containment technology


ISSUE 24: October 2015

Main features

Airborne particle deposition in cleanrooms: Deposition mechanisms
W Whyte, K Agricola and M Derks
This article discusses the mechanisms of particle deposition onto cleanroom surfaces. The main mechanism for particles above about 0.5μm is gravitational settling. Turbulent deposition and electrostatic attraction can also occur at all particle sizes, and for particles below 0.5μm Brownian diffusion is important. Measurements of particle deposition rates (PDRs) were made of particles ≥10μm on witness plates orientated in different directions and exposed in different ventilation conditions, and it was concluded that over 80% of particles were deposited by gravitational sedimentation, and probably more than half of the remainder by turbulent deposition.

Product Oriented Contamination Control (POCC)
Koos Agricola
Product Oriented Contamination Control (POCC) is a systematic method to determine contamination causes of product failure and to determine potential critical control points. A risk assessment then helps to prioritise the critical control points and to determine the type of contamination control solution that would reduce the risk of product failure due to particle contamination during manufacturing.

Importance of risk assessment for aseptic transfer in pharmaceutical compounding
Tim Sandle
Aseptic transfer is a critical contamination control issue, carried out over a series of stages. If any stage is performed in an uncontrolled manner then microbial contamination of a product can occur. Contamination risks can arise from a number of sources, including incoming materials, air and personnel. To address these risks appropriate controls include controlled environments, personnel gowning and behaviour, and the use of disinfectants. This article considers the key risks and risk mitigation strategies using a case study of aseptic transfer within a pharmacy unit for the purpose of preparation or compounding of a medicinal drug product.

Containment and Ebola in an outbreak setting
Allan Bennett, Simon Parks and Tom Pottage
This article describes the diagnostic laboratories commissioned by PHE in Sierra Leone to support Ebola treatment Centres. Specialised isolators were designed, assembled and tested in the UK before being dismantled and shipped to site for reassembly. The isolators were designed and constructed based on the experience of HPE Porton in containment.

Regulatory reflections
EU GMP Annex 1
Tin Eaton



Contec ProChlor validated for sporicidal transfer disinfection
New isolator half-suit from Pharminox Isolation Ltd
DOP Solutions introduces a new cleanroom Airflow Mapper
Edinburgh Molecular Imaging is first customer for Envair Lab’s brand new safety cabinet
Clean Room Construction completes flagship projects in record-breaking year
CHTS helps CL3 lab managers meet increasing demands for evidence of fumigation efficacy
Cleanroom Guangzhou Exhibition 2015 Post-Show Report
Ecolab helps reduce exposure to cytotoxic drugs
Validair launch EasySense wireless sensors for use with ViGIE 2.0 software

Events and Training Courses

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